A manually curated drug discovery community resource on anti-mycobacterial phytomolecules and plant extracts. Currently, BioPhytMol holds a total of 2,582 entries including 188 plant families (comprised of 692 genera and 808 species) and 633 active compounds and plant extracts identified against 25 target mycobacteria. Multiple analysis approaches have been used to prioritize the library for drug-like compounds, for both whole cell screening and target-based approaches. In order to represent the multidimensional data on chemical diversity, physiochemical properties and biological activity data of the compound library, novel approaches such as the use of circular graphs have been employed.
Open Source Drug Discovery (OSDD) Unit, Council of Scientific and Industrial Research, New Delhi, India; Department of Applied Mathematics and Bioinformatics, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India; Department of Bioinformatics, Christ College, Rajkot, Gujarat, India; St. Stephens College, University of Delhi, New Delhi, India; Department of Biochemistry and Molecular Biology, University Clinic of Bonn (UKB), University of Bonn, Bonn, Germany