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Protocols

BioPlex specifications

Information


Unique identifier OMICS_17463
Name BioPlex
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Version 2.0
Maintained Yes

Subtool


  • BioPlex Display

Maintainers


  • person_outline Steven P. Gygi
  • person_outline Wade Harper
  • person_outline Edward Huttlin

Publications for BioPlex

BioPlex citations

 (35)
library_books

A recombinant Fasciola gigantica 14 3 3 epsilon protein (rFg14 3 3e) modulates various functions of goat peripheral blood mononuclear cells

2018
PMCID: 5840819
PMID: 29510740
DOI: 10.1186/s13071-018-2745-4

[…] in sequence from uniprot. P62258 (YWHAE) had a Max score of 313, a Query coverage of 89% and 65% identity. Using P62258 (YWHAE), we queried the following interactions databases: Intact [], String [], BioPlex [], BioGrid []. The resulting interacting pairs were used as input for obtaining the experimental and homology modelled structure interactions using Interactome3D []. All experimental and mode […]

library_books

Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches

2018
Biomed Res Int
PMCID: 5831883
PMID: 29662892
DOI: 10.1155/2018/6346954

[…] d other proteins found in the human WS as described elsewhere []. First, a comprehensive search was performed in eight different databases (BioGRID, HPRD, APID, EMBL-EBI, FpClass, STRING, IntAct, and BioPlex) () to provide a solid list with both known and predicted protein-amylase interactions. Second, a simulated amylase hub containing only the 66 proteins identified in this study was constructed […]

library_books

Identification of seipin linked factors that act as determinants of a lipid droplet subpopulation

2018
PMCID: 5748981
PMID: 29187527
DOI: 10.1083/jcb.201704122

[…] lipid storage conditions (), and seipin has been identified as high-score interactor of promethin in a high-throughput affinity–purification MS approach (https://thebiogrid.org/166968/publication/the-bioplex-network-of-human-protein-interactions-additional-unpublished-ap-ms-results.html), we consider it a promising candidate for an Ldo homologue.More broadly, by aiming to identify the molecular id […]

library_books

A network based meta analysis for characterizing the genetic landscape of human aging

2017
Biogerontology
PMCID: 5765210
PMID: 29270911
DOI: 10.1007/s10522-017-9741-5

[…] ractions or co-complex associations of the encoded proteins, complemented by different types of functional relationships. In particular, the interaction data were retrieved from the resources mentha, BioPlex, and STRING. Human release 2015.11.27 of mentha was used as an integrated interaction network that combines experimentally determined and literature-curated physical protein interactions and c […]

library_books

Exploring digenic inheritance in arrhythmogenic cardiomyopathy

2017
BMC Med Genet
PMCID: 5723071
PMID: 29221435
DOI: 10.1186/s12881-017-0503-7

[…] cribed by Cooper et al. [], a set of PKP2-related genes was compiled based on the following five criteria. (i) The two gene products form a protein complex. Gene complex data were downloaded from the BioPlex database [] version 4. Genes that interacted with PKP2 with a confidence of at least 0.7 were selected. (ii) The two gene products interact functionally. PKP2 interactors were downloaded from […]

library_books

Triethylene glycol dimethacrylate: adjuvant properties and effect on cytokine production

2017
PMCID: 5717717
PMID: 29230430
DOI: 10.1080/23337931.2017.1409075

[…] din-phycoerythrin (SA-PE) conjugate is added to bind to the biotinylated antibody. Phycoerythrin acts as a fluorescent indicator, or reporter. The concentration of the cytokines were measured using a BioPlex 200 instrument equipped with BioManager analysis software (BioRad, Hercules, CA), using red and green lasers to detect the different colors on the beads while measuring the fluorescence intens […]

Citations

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BioPlex institution(s)
Department of Cell Biology, Harvard Medical School, Boston, MA, USA; Biogen Inc., Cambridge, MA, USA
BioPlex funding source(s)
Supported by the National Institutes of Health (U41 HG006673), Biogen K01DK098285, and the Canadian Institutes for Health Research.

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