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BIPA specifications


Unique identifier OMICS_03022
Alternative name Biological Interaction database for Protein-nucleic Acid
Restrictions to use None
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Not allowed
Version 2.1
Maintained No


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Publication for Biological Interaction database for Protein-nucleic Acid

BIPA citations


Probing the accuracy and precision of Hirshfeld atom refinement with HARt interfaced with Olex2

PMCID: 5755575
PMID: 29354269
DOI: 10.1107/S2052252517015548

[…] theory, Table 1). The geometry of a SHELXL IAM refinement served as input. For rubrene, a complete molecule comprising four asymmetric units was used in the wavefunction calculations (Fig. 2 a). For BIPa, the asymmetric unit consisting of the five co-crystallized ions was considered as a supermolecule and used for the wavefunction calculation. To minimize the bias on the ADPs, the ions in the sup […]


Outer Membrane Vesicles (OMV) based and Proteomics driven Antigen Selection Identifies Novel Factors Contributing to Bordetella pertussis Adhesion to Epithelial Cells*

PMCID: 5795387
PMID: 29203497
DOI: 10.1074/mcp.RA117.000045

[…] he proteins already part of the currently available aP formulation, we focused on six promising candidates to be assessed for their adhesive properties and vaccine potential: BrkA, Vag8, TcfA, SphB1, BipA, and BfrD. Interestingly, five of the selected antigens had a predicted autotransporter structure and they were identified with high amino acid sequence coverage in both the passenger domain and […]


In silico, in vitro, X ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease

Sci Rep
PMCID: 5532286
PMID: 28751689
DOI: 10.1038/s41598-017-06411-9

[…] ch compound interacts with Asp171, Gln22, Gln64, Asp168, Gln201, Ser204 and Gly243. In contrast, S-adenosyl-3-thio-1,8-diaminooctane (AdoDATO, PDBID: 2I7C) and 5-(1H-benzimidazol-2-yl)pentan-1-amine (BIPA, PDBID: 4CWA), which are inhibitors of P. falciparum SpdSyn, they bind to both putrescine and dcSAM binding sites in reported co-crystal structures, . Although, compounds 1, 3 and 4 have an amino […]


Autophagy is dispensable to overcome ER stress in the filamentous fungus Aspergillus niger

PMCID: 4985598
PMID: 27027276
DOI: 10.1002/mbo3.359

[…] tophagy is not. Even in the absence of functional ERAD, autophagy is not alternatively taking over its functions in degrading misfolded proteins from the ER.Gene expression levels of UPR target genes bipA and pdiA were higher in strains expressing the misfolded mtGlaA::GFP protein compared to the N402 strain (Fig. ). This suggests the presence of ER stress and has also been demonstrated upon overe […]


Bordetella pertussis Isolates from Argentinean Whooping Cough Patients Display Enhanced Biofilm Formation Capacity Compared to Tohama I Reference Strain

Front Microbiol
PMCID: 4672677
PMID: 26696973
DOI: 10.3389/fmicb.2015.01352

[…] hese studies should be expanded in the future to post-translation and metabolic level to gain a holistic picture of pathogen host adaptation mechanisms.The adhesins tested, namely FHA, Fim3, Prn, and BipA, showed higher transcriptional levels by qRT-PCR in the clinical isolate grown as biofilm compared to the reference strain Tohama I. FHA, one of the main adhesins described for B. pertussis, is i […]


Structural and Functional Analysis of BipA, a Regulator of Virulence in Enteropathogenic Escherichia coli*

PMCID: 4543647
PMID: 26163516
DOI: 10.1074/jbc.M115.659136
call_split See protocol

[…] X-ray crystal diffraction data of full-length BipA of apo and nucleotide-bound states were collected on beamlines 5.0.1 and 5.0.2 at the Advanced Light Source (ALS) at the Lawrence Berkeley National Laboratory (LBNL). Collected data were processe […]


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BIPA institution(s)
Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, Cambridge, UK
BIPA funding source(s)
Supported by Mogam Science Scholarship Foundation.

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