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BitterDB specifications


Unique identifier OMICS_20925
Name BitterDB
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Allowed
Version 1.3
Maintained Yes


  • person_outline Masha Niv

Publication for BitterDB

BitterDB citations


e Bitter: Bitterant Prediction by the Consensus Voting From the Machine Learning Methods

PMCID: 5885771
PMID: 29651416
DOI: 10.3389/fchem.2018.00082

[…] rs (Huang et al., ). In their study, the dataset is composed of 539 bitterants and 539 non-bitterants. Five hundred thirty-nine bitterrants are gathered from the literature and the publicly available BitterDB (Wiener et al., ). For 539 non-bitterants, 20 non-bitterants are from their in-house bitterless compounds validated by the experiments, and 519 non-bitterants are the representative structure […]


Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors

Front Mol Biosci
PMCID: 5797744
PMID: 29445727
DOI: 10.3389/fmolb.2018.00006
call_split See protocol

[…] BitterDB compounds were prepared with LigPrep (version 3.6, Schrödinger, LLC, New York, NY, 2015) through the generation of stereoisomers and protonation states at pH 7 ± 0.5 and then with Phase (vers […]


Bitter or not? BitterPredict, a tool for predicting taste from chemical structure

Sci Rep
PMCID: 5608695
PMID: 28935887
DOI: 10.1038/s41598-017-12359-7
call_split See protocol

[…] Training and test sets generated and/or analysed in the current study are available from the corresponding author upon reasonable request.Matlab code for BitterPredict is provided via BitterDB and via GitHub repository The allowed input is CSV or Excel file holding QikProp and phys […]


Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test case

Sci Rep
PMCID: 5557796
PMID: 28811548
DOI: 10.1038/s41598-017-08344-9
call_split See protocol

[…] chloroquin, chloramphenicol, and coumarin were analyzed as ggTas2r1 agonists. The 3D molecular structures of these compounds were downloaded from the publicly accessible electronic database, chicken BitterDB (http://bitterdb/dbbitter.php?mode_organism=Chicken), and prepared (through the generation of stereoisomers and protonation states at pH 7 ± 0.5) with LigPrep (version 3.6, Schrödinger, LLC, […]


Expanding the fragrance chemical space for virtual screening

J Cheminform
PMCID: 4037718
PMID: 24876890
DOI: 10.1186/1758-2946-6-27

[…] as used. Both datasets were combined and checked for duplicates to a final list of 1760 fragrance molecule structures. For TasteDB structure representations were retrieved from the browsing option of BitterDB [] and from the Sweet-tree of SuperSweet []. Both datasets were combined and checked for duplicates to a final list of 806 taste structures. […]

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BitterDB institution(s)
The Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel; Fritz Haber Center for Molecular Dynamics, The Hebrew University of Jerusalem, Israel
BitterDB funding source(s)
Supported by Niedersachsen-Israel Research cooperation fund and BSF grant number 2007296.

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