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Blaze specifications


Unique identifier OMICS_19689
Name Blaze
Alternative name FieldScreen
Software type Application/Script
Interface Graphical user interface
Restrictions to use None
Computer skills Medium
Stability Stable
Maintained Yes


  • person_outline Timothy Cheeseright <>

Publication for Blaze

Blaze citations


Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter

PMCID: 5326799
PMID: 28289374
DOI: 10.3389/fnmol.2017.00040

[…] were cultured in dmem:f12 with glutamine (gibco # 11320-033) supplemented with 15% fbs and 1x neaa (thermofisher scientific)., the cresset field based virtual screening tool, blaze (formerly called fieldscreen), (cheeseright et al., , ) was utilized to search the full pfizer compound screening collection to identify compounds similar to literature cht positive allosteric modulator (pam) […]


Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1

PMCID: 4623604
PMID: 26507530
DOI: 10.1038/srep15686

[…] model in the next round of screening., the consensus field maps for group 1 and 2 molecules were used to query a database of 10,455 fragment-like molecules from chemdiv ( using the fieldscreen module in forge. of the 215 molecules with the highest field similarity scores, 184 compounds were purchased. however, 106 of these were poorly soluble under our assay conditions […]


Three Dimensional Compound Comparison Methods and Their Application in Drug Discovery

PMCID: 5005041
PMID: 26193243
DOI: 10.3390/molecules200712841

[…] representations: e.g. bci [], rascal [], molprint2d [], and simcomp [], which use two-dimensional structure fingerprint or graph matching3d representations: e.g. rocs [], usr [], pl-patchsurfer [], fieldscreen [] that use 3d features such as volume, atomic distances, surfaces, or fields., 1d representations: e.g. smiles [], smarts [], 2d representations: e.g. bci [], rascal [], molprint2d [], […]


Small Molecule facilitated Degradation of ANO1 Protein

PMCID: 4036244
PMID: 24599954
DOI: 10.1074/jbc.M114.549188

[…] information available and are not readily accessible via experimentation., virtual screens and pharmacophore alignments were performed with the cresset suite of programs, including fieldalign and fieldscreen (, ). structure-activity relationship and quantitative structure-activity relationship analysis were performed using schrödinger's chemoinformatics program, canvas (canvas, version 1.5, […]


Cavka – a new automatic pharmacophore elucidation method in progress

PMCID: 3083587
DOI: 10.1186/1758-2946-3-S1-P31

[…] ligand-receptor interactions to highlight important ligand features to be selected for creating pharmacophore models automatically. the performance is evaluated in a retrospective screening on the fieldscreen [] dataset outlining strengths, weaknesses and as well as similarities of each method for the scrutinized […]


Optimal assignment methods for ligand based virtual screening

PMCID: 2820492
PMID: 20150995
DOI: 10.1186/1758-2946-1-14

[…] field methods like grid [] or comfa [] were originally introduced in the field of quantitative structure-activity relationship modelling (qsar) but are also suitable for vs experiments []. fieldscreen, a recently published method by cheeseright et al. [], uses four different types of molecular fields and reduces these fields to the local maximal values. these values, referred […]

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Blaze institution(s)
Cresset BioMolecular Discovery Ltd., BioPark Hertfordshire, Hertfordshire, UK

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