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BLiC specifications


Unique identifier OMICS_20543
Name BLiC
Alternative name Bayesian Likelihood 2-Components
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes


  • Plants and Fungi
    • Saccharomyces cerevisiae


No version available


  • person_outline Nir Friedman

Publication for Bayesian Likelihood 2-Components

BLiC citations


Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA Targets

PLoS Biol
PMCID: 4654594
PMID: 26587879
DOI: 10.1371/journal.pbio.1002307

[…] each motif search can be found in .To statistically assess the similarity between motifs, we used position frequency matrices from the six positions downstream of UGUA as input to MotifComparison (p-BLiC, 100 shuffles, no shift permitted between matrices) in the MotifSuite []. MotifComparison calculated the p-value of the Bayesian Likelihood 2-Component (BLiC) score [], and we considered two moti […]


A functional selection model explains evolutionary robustness despite plasticity in regulatory networks

Mol Syst Biol
PMCID: 3501536
PMID: 23089682
DOI: 10.1038/msb.2012.50

[…] sing all motifs from S. cerevisiae, as described below). We confirmed that the random motifs we constructed were not similar to any known motifs, comparing the random motifs to all known motifs using BLiC (). For each random motif, we scanned for targets in each species (as described above), and ran CladeoScope to reconstruct the ancestral sets. We then computed an empirical P-value for each motif […]


Yin Yang 1 extends the Myc related transcription factors network in embryonic stem cells

Nucleic Acids Res
PMCID: 3333890
PMID: 22210892
DOI: 10.1093/nar/gkr1290

[…] terature (), and used to build a custom set of 597 models. The YY1 putative binding site identified through de novo motif discovery was added to this set. For some analyses, PWMs were clustered using BLiC (). In this way we could reduce the complexity of our results using a non-redundant set of 229 PWMs.In order to identify over-represented PWMs in the YY1 putative binding sites proximal (±2.5 kb […]


Extensive protein and DNA backbone sampling improves structure based specificity prediction for C2H2 zinc fingers

Nucleic Acids Res
PMCID: 3113574
PMID: 21343182
DOI: 10.1093/nar/gkr048

[…] g specificity predictions, we used a simple metric that counted the number of positions at which the preferred base in prediction and experiment agree. We also implemented a simplified variant of the BLiC score, a recently introduced similarity measure for comparison of PFM columns (). The BLiC score is based on the Jensen–Shannon divergence, a standard measure of the distance between two probabil […]


Inferring PDZ Domain Multi Mutant Binding Preferences from Single Mutant Data

PLoS One
PMCID: 2956758
PMID: 20976110
DOI: 10.1371/journal.pone.0012787

[…] ight be beneficial for cases like the PDZ domain, where the degree of specificity in the ligand columns varies greatly. A biologically-motivated function, such as the Bayesian Likelihood 2-Component (BLiC) function, might better highlight the essential differences, and similarities, between a given pair of PWMs. […]

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BLiC institution(s)
School of Computer Science and Engineering, The Hebrew University, Jerusalem, Israel; Department of Molecular Genetics and Biotechnology, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
BLiC funding source(s)
Supported by grants from the Israeli Science Foundation administered by the Israeli Academy of Sciences and Humanities, The Israeli Cancer Research Foundation, the Human Frontiers Science Program, and the National Institutes of Health.

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