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Track and control your code with version control systems

Software codes are constantly evolving, become more complex as newer versions are released. But sometimes errors and bugs occur and being able to retrieve the latest stable version of your software code can be a life-saver. For this, most software code repositories are equipped with version control systems (VCS). Why do you need version control and how is it implemented? Software developers working in teams are continually writing new source code and changing existing source code. The code for a project is typically organized in a folder structure or “file tree”. One developer on the team may be working on a new feature while another developer fixes an unrelated bug by changing code, each developer may make their changes in …

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CircRNAs in human and mouse tissues

Leng Han and Chunjiang He are the creators of the tissue-specific circular RNA (circRNA) database TSCD. They performed the first global analysis of tissue-specific circRNAs and collected these data in a comprehensive database. Here, they talk about their work and how the TSCD database can help researchers explore their RNA sequencing data. A repository of more than 300,000 tissue-specific RNAs With circRNAs attracting more attention in transcriptome research, we explored the global features of tissue-specific circRNAs in embryo development and organ differentiation. To identify tissue specific circRNAs, 3 algorithms, CIRI, circRNA_finder and find_circ, were applied to RNA-seq data collected from the ENCODE project and the NCBI GEO database.   Based on the major types of circRNA, we identified more than 300,000 tissue-specific circRNAs in different tissues. Our …

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6 ways biorepositories support clinical research

Biorepositories help research institutions by providing tissue samples for clinical studies. Human tissue samples play a critical role in disease research by enabling assessments of molecular expression, prediction of toxicity, and identification of biomarkers. They help clarify and expand field-of-use claims, selection of appropriate species for preclinical studies and they assist in the clinical trial stages of drug development. Below is a list of key areas where availability of tissues (both from humans and preclinical species) can support pharmaceutical and other research. Assessment of Molecular Expression Biobanks contain vast libraries of human tissue samples, allowing for the assessment of expression levels of biological target molecules such as proteins and RNA. Methods include immunohistochemistry, in situ hybridization, western blotting, PCR and tissue microarrays, all …

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