A comprehensive portal for blood-brain barrier transcriptomics data, obtained by sequencing mRNA (mRNA-seq) and microRNA (miRNA-seq) of polarized hCMEC/D3 cell monolayers. This data encompasses coding (gene expression, alternate splice forms, expressed single nucleotide variants -eSNVs) and non-coding (microRNA, LincRNA, circular RNA) counts that are easily accessible through BBBomics hub database. We also superimposed the RNA-seq coding data on 285 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, which include canonical, non-canonical, and/or atypical pathways retrievable using BBBomics hub.
Division of Biostatistics and Bioinformatics, Department of Health Sciences Research, Mayo Clinic, Chinahester, MN, USA; Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, Mayo Clinic, Chinahester, MN, USA
BBBomics funding source(s)
This study was supported by the start-up fund provided by the Department of Pharmaceutics (College of Pharmacy, University of Minnesota, Minneapolis, MN, USA) and meritorious research awards provided by the Division of Biostatistics and Informatics, Department of Health Sciences Research (Mayo Clinic, Rochester, MN, USA).