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A comprehensive portal for blood-brain barrier transcriptomics data, obtained by sequencing mRNA (mRNA-seq) and microRNA (miRNA-seq) of polarized hCMEC/D3 cell monolayers. This data encompasses coding (gene expression, alternate splice forms, expressed single nucleotide variants -eSNVs) and non-coding (microRNA, LincRNA, circular RNA) counts that are easily accessible through BBBomics hub database. We also superimposed the RNA-seq coding data on 285 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, which include canonical, non-canonical, and/or atypical pathways retrievable using BBBomics hub.

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None
Community driven:
No
Data access:
File download, Web user interface
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Institution(s)

Division of Biostatistics and Bioinformatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Pharmaceutics and Brain Barriers Research Center, University of Minnesota, Minneapolis, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA

Funding source(s)

This study was supported by the start-up fund provided by the Department of Pharmaceutics (College of Pharmacy, University of Minnesota, Minneapolis, MN, USA) and meritorious research awards provided by the Division of Biostatistics and Informatics, Department of Health Sciences Research (Mayo Clinic, Rochester, MN, USA).

  • (Kalari et al., 2016) BBBomics-Human Blood Brain Barrier Transcriptomics Hub. Frontiers in neuroscience.
    PMID: 26973449
  • Animals
    • Homo sapiens
  • (Akhtar et al., 2016) Bioinformatic tools for microRNA dissection. Nucleic acids research.
    PMID: 26578605

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