BRAID specifications


Unique identifier OMICS_29573
Alternative name Bivariate Response to Additive Interacting Doses
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes


  • braidReports
  • braidrm


No version available


  • person_outline Anang Shelat

Publication for Bivariate Response to Additive Interacting Doses

BRAID citation


BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism

Sci Rep
PMCID: 5738392
PMID: 29263342
DOI: 10.1038/s41598-017-18068-5

[…] nts and only then, the FLM model is a special case of the LA model, and by extension the BIGL model. In all other cases, the model is mathematically convenient, but biochemically uninterpretable. The BRAID model of Twarog et al. is another method that adheres to the LA constraints, thus building on the Hill dose response for the individual compounds and satisfying the Loewe self-combination addit […]

BRAID institution(s)
Departments of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, USA; Developmental Neurobiology St. Jude Children’s Research Hospital, Memphis, TN, USA
BRAID funding source(s)
Supported by the American Lebanese Syrian Associated Charities (ALSAC).

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