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Associated diseases

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Breaking-Cas specifications

Information


Unique identifier OMICS_13525
Name Breaking-Cas
Interface Web user interface
Restrictions to use None
Input data One or several DNA sequences up to 20,000 nucleotides in total
Input format FASTA
Output data Rich interactive web page containing detailed information about candidate oligos, on-targets and off-targets. Scores, coordinates and overlapping genes are shown. Mini genome browsers allow checking the genomic environment of each putative off-target. Results can be downloaded as tables.
Programming languages Javascript, PHP
Computer skills Basic
Stability Stable
Maintained Yes

Documentation


Maintainer


  • person_outline Florencio Pazos <>

Publication for Breaking-Cas

Breaking-Cas in publication

PMCID: 5404925
PMID: 28438259
DOI: 10.7554/eLife.21476.035

[…] chose showed very few off-targets in exonic regions and none in other or genes. we have now further applied two more tools to predict potential off-targets –cctop (stemmer et al. plos one 2015) and breaking-cas (olvieros et al. nar 2016) – and obtained 84 and 193 for the upstream grna (u-grna) and 132 and 206 for the downstream grna (d-grna), respectively:, , only three or genes […]


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Breaking-Cas institution(s)
National Centre for Biotechnology (CNB-CSIC), c/ Darwin 3, Madrid, Spain; CIBERER, ISCIII, Madrid, Spain
Breaking-Cas funding source(s)
This work was supported by Spanish Ministry for Economy and Competitiveness (MINECO) [BIO2011-25687, BIO2012-39980, BIO2014- 57011-R].

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