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BRENDA specifications


Unique identifier OMICS_02681
Alternative name BRaunschweig ENzyme DAtabase
Restrictions to use Academic or non-commercial use
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Not allowed
Maintained Yes



  • person_outline Dietmar Schomburg

Additional information

Publications for BRaunschweig ENzyme DAtabase

BRENDA citations


Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell Walls of Algal Ancestors of Land Plants

Genome Biol Evol
PMCID: 4494064
PMID: 25977457
DOI: 10.1093/gbe/evv090
call_split See protocol

[…] ces within each pectinase gene family to represent the diversity of gene sequences, based on the information at the Carbohydrate Active Enzyme site (, last accessed November 2014) and the Braunschweig Enzyme Database (, last accessed November 2014). The sequences from the BLASTp results were searched against the Conserved Domain Database (), and any sequences with […]


Efficient CO2 Reducing Activity of NAD Dependent Formate Dehydrogenase from Thiobacillus sp. KNK65MA for Formate Production from CO2 Gas

PLoS One
PMCID: 4111417
PMID: 25061666
DOI: 10.1371/journal.pone.0103111

[…] -reducing activities.In this study, we attempted to identify FDHs that are superior to a conventional CO2-reducing biocatalyst, i.e., CbFDH. FDHs suitable for CO2 reduction were screened from BRENDA (BRaunschweig ENzyme Database, based on their optimum pH. The catalytic mechanism of formate oxidation by NAD-dependent FDHs has been demonstrated to involve direct hydr […]


Enzyme Reaction Annotation Using Cloud Techniques

Biomed Res Int
PMCID: 3814047
PMID: 24222895
DOI: 10.1155/2013/140237

[…] gh-level profiles from sequences to represent and determine protein catalytic functions. The EnzymeDetector [] annotation method uses sequence similarity analysis and a comprehensive enzyme database, BRaunschweig ENzyme DAtabase (BRENDA) [], which is manually extracted from the literature. The Enzyme Function Inference by Combined Approach (EFICAz) [] method adopts and combines various independent […]


Genome wide metabolic (re ) annotation of Kluyveromyces lactis

BMC Genomics
PMCID: 3508617
PMID: 23025710
DOI: 10.1186/1471-2164-13-517

[…] y of genomic and biological information and is maintained and updated by curators. The SGD was selected as the second reference database for this project.• The Comprehensive Enzyme Information System BRaunschweig ENzyme DAtabase (BRENDA – provides enzyme functional data obtained directly from literature by professional curators []. This database was used to confirm […]


Application of Top Down and Bottom up Systems Approaches in Ruminant Physiology and Metabolism

Curr Genomics
PMCID: 3401895
PMID: 23372424
DOI: 10.2174/138920212801619269

[…] abases include NCBI [], EntrezGene [], UCSC Genome Browser [], UniPort [] and BGD (Bovine Genome Database) []; biochemical databases include KEGG (Kyoto Encyclopedia of Genes and Genomes) [], BRENDA (BRaunschweig ENzyme DAtabase) [,], PubChem identifier [], CAS (Chemical Abstracts Service) [], CheBI (Chemical Entities of Biological Interest) [], and Transport DB []; and among the metabolic- and or […]


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BRENDA institution(s)
Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universitat Braunschweig, Braunschweig, Germany
BRENDA funding source(s)
Supported by German Federal Ministry of Education and Research (BMBF) [031A539D, 0316188B, 0316188F, 031L0078E, 031L0078G].

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