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BTO specifications


Unique identifier OMICS_21000
Name BTO
Alternative name BRENDA Tissue Ontology
Restrictions to use Academic or non-commercial use
Database management system MySQL
Community driven No
Data access File download, Browse
User data submission Allowed
Version 1.2
Maintained Yes


  • person_outline Dietmar Schomburg
  • person_outline Sandra Placzek

Additional information

Publications for BRENDA Tissue Ontology

BTO citations


iCTNet2: integrating heterogeneous biological interactions to understand complex traits

PMCID: 4706053
PMID: 26834985
DOI: 10.5256/f1000research.7350.r9869

[…] ne database miRCat (, which in turn, assembles data from five databases:, miRTarBase, tarbase, microT (v3.0) and miR2Disease. Tissues. Tissue types were taken from BRENDA tissue ontology . We rooted the ontology at ‘whole body’ (BTO:0001489) to exclude the non-animal tissue portions of the ontology. Drugs. We used the CTD as the primary resource for drugs as ref […]


Learning to Recognize Phenotype Candidates in the Auto Immune Literature Using SVM Re Ranking

PLoS One
PMCID: 3796529
PMID: 24155869
DOI: 10.1371/journal.pone.0072965

[…] enotype terms from the Mammalian Phenotype Ontology (MP) with 23,700 synonyms, 1400 quality terms from PATO with 2,200 synonyms, species terms from the Linnaeus tool and 5,400 anatomy terms from the Brenda Tissue Ontology with 9,600 synonyms. This is exemplified in .We evaluate several alternative approaches for hypothesis selection in the merge module by comparing our previous priority list app […]


The BioPAX Validator

PMCID: 3789551
PMID: 23918249
DOI: 10.1093/bioinformatics/btt452

[…] rently uses seven OBO ontologies (as recommended in the BioPAX L3 specification): PSI-MI (molecular interactions), PSI-MOD (post-translational modifications), GO (gene ontology), CL (cell type), BTO (BRENDA tissue ontology), PATO (phenotypes) and SO (sequence ontology). To verify that terms from these ontologies are correctly used, the validator caches each controlled vocabulary locally for perfor […]


A guide to the Proteomics Identifications Database proteomics data repository

PMCID: 2970915
PMID: 19662629
DOI: 10.1002/pmic.200900402

[…] a match to any child term of the selected term. For instance, a search on tissue term “brain” will also return datasets annotated as “cerebral cortex,” as the latter is specified in the corresponding BRENDA Tissue Ontology to be “a part of” brain, and is therefore automatically included in the actual query executed by PRIDE.The “PRIDE BioMart” interface (see below).The “Advanced Search” form allow […]


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BTO institution(s)
Technische Universitat Braunschweig, Braunschweig Integrated Centre of Systems Biology (BRICS), Braunschweig, Germany
BTO funding source(s)
Supported by German Federal Ministry of Education and Research (BMBF) [01KX1235, 0316188 F, 031A539D]; Ministry of Science and Culture of Lower Saxony, Germany [74ZN1122].

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