An online bioinformatics resource that provides biologists with directional relationships between drugs and genes/proteins in specific disease contexts based on network mining, literature mining, and drug effect annotating. C2Maps is based on the concept of network pharmacology by examining many drugs at the same time and studying the drug disease relationship based on the underlying protein interaction network instead of drugs' direct target. C2Maps provides quantitative measurements of protein's and drug's relevance to a specific disease by applying networking mining and the statistical testing methods in text mining and thus offers new insight to assess overall drug efficacy and toxicity. The case study on breast cancer correlates very well with the existing pharmacology of the two breast cancer drugs and highlights the significance of C2Maps database.
School of Informatics, Indiana University, Indianapolis, IN, USA; Indiana Center for Systems Biology and Personalized Medicine, Indianapolis, IN, USA; Department of Computer Science and Technology, Shandong College of Electronic Technology, Jinan, China; Biology Department, School of Science, Indiana University, Indianapolis, IN, USA; School of Informatics, Indiana University, Indianapolis, IN, USA