Helps scientists explore the functional role of C-termini in proteins of interest. C-Terminome contains thousands of C-terminal minimotifs with known function. Functions of other C-termini can be investigated based upon predictions inferred from experiments in rodents, predicted from known consensus sequences for minimotifs functions, and from new anchored consensus sequences on the C-terminus. The C-terminome web system enables a new approach for connecting proteins with poorly understood functions to other proteins that have more established roles in molecular reactions, pathways, or cell processes.
Nevada Institute of Personalized Medicine, and School of Life Sciences, University of Nevada, Las Vegas, NV, USA; Department of Computer Science and Engineering, University of Connecticut, Storrs, CT, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
C-Terminome funding source(s)
The National Institutes of Health grants R15 GM107983, R01 GM079689 and R01 LM010101; The Graduate and Professional Students Association, University of Nevada, Las Vegas