Computational protocol: Topological Analysis for Arteriovenous Malformations via Computed Tomography Angiography: Part 2: Practical Application

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Protocol publication

[…] Thereafter, data were processed using ImageJ version 1.46 (National Institutes of Health, Bethesda, Md.) open source image processing software and the BoneJ version 1.3.9 plug-in. Rendered areas were binarized into monochrome images with the command “Make Binary,” and the vascular lumen was converted into a 3D structure with clearly defined borders (Fig. B) [...] To evaluate the difference between normal and AVM vessel structure, the Mann–Whitney U test was applied to loop density of control group and initial examination of AVM group. To evaluate the topological transformation caused by medical intervention, the Wilcoxon signed-rank test was applied to result of vascular lumen capacity, number of loops, and loop density in both pre- and postprocedural examination.All statistical analyses were performed using statistical software (IBM SPSS Statistics version 19, IBM, Armonk, N.Y.), and a P value <0.05 was considered to indicate a statistically significant difference. […]

Pipeline specifications

Software tools ImageJ, BoneJ, SPSS
Applications Miscellaneous, Microscopic phenotype analysis
Diseases Arteriovenous Malformations