Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 48
Release date: Mar 7 2014
Last update date: Oct 11 2016
Access: Public
Diseases: Multiple Sclerosis
Dataset link Integrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)

Experimental Protocol


Patients with seasonal allergic rhinitis (SAR) show considerable variations in response to glucocorticoids (GCs) treatment. Peripheral blood mononuclear cells (PBMCs) were collected from 8 high responders (HR) and 8 low responders (LR) to GC treatment. PBMCs were challenged with diluent, grass pollen extract (ALK-Abelló A/S; 100 μg/mL) as well as grass pollen extract plus glucocorticoids (100ug/mL) for one week. Total CD4+ T cells were enriched for the gene expression microarray analysis, which was performed using SurePrint G3 Human Gene Expression 8X60K microarrays.

Repositories


GEO

GSE44956

ArrayExpress

E-GEOD-44956

BioProject

PRJNA192689

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Contact


Hui Wang