Computational protocol: Bronchial Responsiveness to Dry Air Hyperventilation in Smokers May Predict Decline in Airway Status Using Indirect Methods

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Protocol publication

[…] Data are presented as mean and standard deviation, 95 % confidence interval, or median [lower—upper quartile]. The Mann–Whitney U test was used to test differences among numerical variables, and Fisher’s exact test was used for binary variables. Univariable and multivariable logistic regression analyses were used to determine whether any variable was associated with BHR, and the results were expressed as odds ratios. Pearson’s correlation coefficient was calculated to study the association between responses to challenge and pulmonary function. Receiver-operated curve (ROC) analyses were performed to identify smokers with rapid deterioration in airway status. A p-value of ≤0.05 was considered to be statistically significant. Two-sided tests were used throughout. Statistical analyses were performed using the commercially available statistical programs STATISTICA version 9 (StatSoft Inc., Tulsa, OK, USA, www.statsoft.com) and SAS/Stat software version 9.2 of the SAS System for Windows (SAS Institute Inc., Cary, NC, USA). ROC analyses were performed using MedCalc Statistical Software (Mariakerke, Belgium). […]

Pipeline specifications

Software tools Statistica, MedCalc
Application Miscellaneous
Organisms Nicotiana tabacum
Diseases Bronchial Diseases, Pulmonary Disease, Chronic Obstructive