|Application:||ChIP-seq analysis, RNA-seq analysis|
|Number of samples:||103|
|Release date:||Sep 8 2015|
|Last update date:||Oct 24 2018|
|Diseases:||Leukemia, Neoplasms, Leukemia, Myeloid, Acute, Hematologic Neoplasms|
|Dataset link||Transcriptional plasticity promotes primary and acquired resistance to BET bromodomain inhibition|
RNA-Seq of DMSO- or JQ1-treated cancer cell lines; ChIP-seq for H3K36me3 and H3K27me3 in a leukemia cell line treated either with DMSO or JQ1, ChIP-seq for H3K27ac in resistant and sensitive mouse and human leukemia. Functional enhancer mapping (STARR-seq) in K-562 treated either with DMSO or JQ1.