Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 15
Release date: Feb 8 2007
Last update date: Feb 18 2018
Access: Public
Diseases: Cardiomyopathy, Hypertrophic, Heart Failure
Dataset link Cardiac-specific deletion of ménage-à-trois-1 (MAT1)

Experimental Protocol


MAT1F/F mice (Korsisaari et al., 2002) were bred with mice expressing Cre recombinase under the control of the cardiomyocyte-specific α-myosin heavy chain (αMHC) promoter (Gaussin et al., 2002a) and back-bred to MAT1F/F mice to generate the cardiac-specific knockout (αMHC-Cre+/0; MAT1F/F; CKO; Fig. 1A, B). Control mice were αMHC-Cre+/0; MAT1F/+ littermates, differing by the presence of one wild-type MAT1 allele, and excluding Cre-mediated toxicity as a basis for phenotypic disparity. Cardiac RNA samples were analyze at 2 or 4 weeks of age (N = 3-5 for each condition tested.

Repositories


GEO

GSE6662

ArrayExpress

E-GEOD-6662

BioProject

PRJNA98623

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Contact


Michael Schneider