|Application:||Gene expression microarray analysis|
|Number of samples:||15|
|Release date:||Feb 8 2007|
|Last update date:||Feb 18 2018|
|Diseases:||Cardiomyopathy, Hypertrophic, Heart Failure|
|Dataset link||Cardiac-specific deletion of ménage-à-trois-1 (MAT1)|
MAT1F/F mice (Korsisaari et al., 2002) were bred with mice expressing Cre recombinase under the control of the cardiomyocyte-specific α-myosin heavy chain (αMHC) promoter (Gaussin et al., 2002a) and back-bred to MAT1F/F mice to generate the cardiac-specific knockout (αMHC-Cre+/0; MAT1F/F; CKO; Fig. 1A, B). Control mice were αMHC-Cre+/0; MAT1F/+ littermates, differing by the presence of one wild-type MAT1 allele, and excluding Cre-mediated toxicity as a basis for phenotypic disparity. Cardiac RNA samples were analyze at 2 or 4 weeks of age (N = 3-5 for each condition tested.