Computational protocol: A dosimetric evaluation of knowledge‐based VMAT planning with simultaneous integrated boosting for rectal cancer patients

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Protocol publication

[…] The following metrics were evaluated to appraise the dosimetric difference between the knowledge‐based and experience‐based planning: 1) homogeneity index (HI) of PTVboost and PTV, defined as (D2%–D98%)/D50%;2) conformity index of PTVboost (CIPTVboost) and PTV (CIPTV), defined as the volume enclosed by the corresponding prescription isodose surface divided by the target volume; 3) the relative volume of the hot spot exceeding 107% of prescribed dose in PTVboost(V107%,i.e.V54.14Gy);4) the dose to the 50% of the femoral head and urinary bladder volume (D50%_FH and D50%_UB);5) the mean dose to the femoral head and urinary bladder (Dmean_FH and Dmean_UB); and 6) total monitor units (MU). Moreover, based on an in‐house MATLAB code (MathWorks, Natick, MA) and the DVH data exported in tabular format, the dose‐volume metrics were averaged over the 70 patients in each planning technique group for plotting comparison.Based on SPSS (V 21.0), paired samples t‐test was used to compare the data couples when the normality test was passed, otherwise Wilcoxon signed‐rank test was performed to analyze the differences. The significance level was put to p < 0.05 (two‐tailed). All the plotting was performed by SigmaPlot software Version 10.0 (Systat Software, Inc., San Jose, CA). […]

Pipeline specifications

Software tools SPSS, SigmaPlot
Application Miscellaneous
Organisms Homo sapiens, Peru tomato mosaic virus
Diseases Neoplasms, Prostatic Neoplasms