Computational protocol: Immediate effects of exercise intervention on cancer-relatedfatigue

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Protocol publication

[…] The subjects were cancer patients hospitalized at the Cancer Center, Department of Radiology, Chemotherapy Center, or Department of Hematology at our hospital from August 1, 2012 to July 31, 2013. Patients were included if they underwent radiation and/or chemotherapy for cancer and performed exercise therapy in the form of leg strength and walking training under the guidance of a physical therapist. Patients were excluded if assessments were difficult because of reduced cognitive function, if they had difficulty performing exercise therapy, or if CRF was not evaluated.CRF is normally evaluated in clinical practice immediately before and after exercise therapy on the 1st or 2nd day of physiotherapy for CRF management. We retrospectively collected the results of these CRF evaluations, as well as data regarding gender, age, body mass index, performance status (PS), type of cancer, types of treatment, and the Barthel index (BI) from electronic medical records. This study was approved by our university’s ethics committee (No. H-25–162).CRF was evaluated using the Cancer Fatigue Scale (CFS)), which is a self-administered questionnaire developed to assess fatigue due to cancer. The CFS is a multidimensional scale consisting of three subscales: physical subscale (CFS physical), affective subscale (CFS affective), and cognitive subscale (CFS cognitive). The reliability, validity, and feasibility of the CFS were confirmed by a previous study). The 15 questions included in the CFS are rated from 1–5 (1 no, 2 a little, 3 somewhat, 4 considerably, 5 very much) based on the patient’s current condition. These scores are used to calculate scores for each subscale, as well as a total scale score (CFS total). For all scales, higher scores indicate more severe fatigue. The maximum scores are 28 points for CFS physical, 16 points for CFS affective, 16 points for CFS cognitive, and 60 points for CFS total. Patients whose CFS total is ≥19 points are considered to have severe fatigue). The physical therapist in charge of each case handed the CFS questionnaire to the patient, and entered the score into the patient’s electronic medical record.The types of exercise therapy were standing-sitting training to strengthen the leg muscles and walking training to improve walking ability. For both exercises, intensity was set using the Borg category-ratio scale (CR-10), which is a subjective marker of exercise intensity). In standing-sitting training, patients were asked to repeatedly stand up and sit down until they felt the intensity was equivalent to a rating of 4 (somewhat strong) on the CR-10. This number of repetitions was considered as one set, and each participant performed three sets in total. In walking training, patients were asked to walk continuously until they felt intensity equivalent to a rating of 4 (somewhat strong) on the CR-10. Again, this number of repetitions was considered as one set, and each participant performed three sets in total. The total duration of the exercise session was 20–40 min, including standing-sitting and walking.After confirming the normality of the data with the Shapiro-Wilk test, the CFS scores before and after exercise were compared using a paired t-test. IBM SPSS version 21.0 for Windows (IBM Corp., Armonk, NY, USA) was used for the analysis. The significance level was set at 5%. G*Power 3.1.9.2) was used to calculate Cohen’s d-values to determine the effect sizes in the paired t-tests. A Cohen’s d-value of 0.20 was considered “small,” 0.50 was considered “medium,” and 0.80 was considered “large”). […]

Pipeline specifications

Software tools SPSS, G*Power
Application Miscellaneous
Organisms Homo sapiens
Diseases Neoplasms