Computational protocol: Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes

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Protocol publication

[…] Predicted three-dimensional structures for the forkhead DNA-binding domain (DBD) (residues 335–423) of normal and variant FOXP3 proteins were generated using SWISS-MODEL (http://swissmodel.expasy.org/), an Internet-based tool for automated comparative protein modeling (). Structures were visualized and images were generated using either MDL Chime (Symyx Technologies) or DeepView (Swiss-PdbViewer) programs (). […]

Pipeline specifications

Software tools SWISS-MODEL, Chime, Swiss-PdbViewer
Databases ExPASy
Applications Drug design, Protein structure analysis
Organisms Homo sapiens
Diseases Autoimmune Diseases, Diabetes Mellitus, Hypothyroidism, Nephrotic Syndrome, Polyendocrinopathies, Autoimmune, Chronobiology Disorders, Genetic Diseases, X-Linked