Computational protocol: Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population

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Protocol publication

[…] SNPs were tested for deviation from Hardy-Weinberg equilibrium by chi-square test. Categorical data were compared by Fisher's exact test and allelic expression level by one-way ANOVA. The allele and genotype frequencies, odds ratios (ORs) with 95% confidence intervals (95% CIs), and p values were analyzed by use of PLINK 1.07[]. Pairwise LD was measured by use of Haploview 4.2. Five-locus haplotypes were estimated with a full-precise-iteration (FPI) algorithm by use of the online SHEsis software[]. A p < 0.05 was considered statistically significant. […]

Pipeline specifications

Software tools PLINK, Haploview
Application GWAS
Organisms Homo sapiens
Diseases Asthma