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CamSol specifications


Unique identifier OMICS_11321
Name CamSol
Interface Web user interface
Restrictions to use Academic or non-commercial use
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Michele Vendruscolo

Publication for CamSol

CamSol citations


Conformational dynamics in crystals reveal the molecular bases for D76N beta 2 microglobulin aggregation propensity

Nat Commun
PMCID: 5916882
PMID: 29695721
DOI: 10.1038/s41467-018-04078-y

[…] inor substates are characterized by a significantly lower β-sheet content (~38 and 30% for wt and D76N, respectively).Fig. 4An analysis of the predicted solubility of the two ensembles performed with CamSol shows that the D76N mutation in the sequence causes a small reduction of the solubility for residues 74–77 (Supplementary Fig. ). The solubility profiles corrected for the structure and average […]


Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules

Biotechnol Bioeng
PMCID: 5900942
PMID: 29315487
DOI: 10.1002/bit.26543

[…] t al., ), and PASTA (Trovato, Seno, & Tosatto, ) can be used to predict the presence of aggregation‐prone regions (APRs) within proteins using protein primary sequence information alone. In addition, CamSol (Sormanni, Aprile, & Vendruscolo, ) and SAP can be used to predict aggregation‐prone (poorly soluble) surface‐exposed regions (Chennamsetty, Voynov, Kayser, Helk, & Trout, ; Trainor, Broom, & M […]


Rational identification of aggregation hotspots based on secondary structure and amino acid hydrophobicity

Sci Rep
PMCID: 5573320
PMID: 28842596
DOI: 10.1038/s41598-017-09749-2

[…] ens of mutations simultaneously, based on the results of multiple sequence alignment (MSA) and structural data, . In addition, hotspots can be predicted using software such as AGGRESCAN, SolubiS, and CamSol.For such difficult cases, learning from successful examples in previous research would facilitate development of a new method of estimation. In a previous study, we discovered a phenomenon invo […]


Rapid and accurate in silico solubility screening of a monoclonal antibody library

Sci Rep
PMCID: 5558012
PMID: 28811609
DOI: 10.1038/s41598-017-07800-w

[…] n laboratory-constructed library, have a high degree of sequence similarity, methods of predicting solubility changes upon mutation are particularly well-suited for this purpose. In this context, the CamSol method of predicting solubility changes upon mutations, and in particular the sequence-based intrinsic solubility score, may be particularly helpful. To test this strategy, in this work we perf […]


Bottleneck in secretion of α amylase in Bacillus subtilis

Microb Cell Fact
PMCID: 5518135
PMID: 28724440
DOI: 10.1186/s12934-017-0738-1

[…] gate before transporting through Sec secretion system. Also, unfolded α-amylase is less soluble than folded one because we find α-amylase precursor (accession number H9BPX5) poorly soluble when using CamSol [] to compute its solubility (Fig. ).Fig. 1 Although PrsA serves as a post-translocation chaperone to help the folding of secreted proteins and similar chaperones, peptidyl-prolyl cis/trans iso […]


Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

Sci Adv
PMCID: 5479649
PMID: 28691099
DOI: 10.1126/sciadv.1700488

[…] (ii) we select the most promising peptide by using the scores from the cascade methods itself, which are related to the predicted binding (), as well as the predicted solubility calculated using the CamSol method (performing these two steps takes only a few minutes on a standard laptop) (); and (iii) we then graft the selected complementary peptide onto the CDR3 of a human VH (variable region of […]

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CamSol institution(s)
Department of Chemistry, University of Cambridge, Cambridge, UK

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