CanBind

A computational pipeline for mapping large-scale cancer exome data across patients onto protein structures, and automatically extracting proteins with an enriched number of mutations affecting their nucleic acid, small molecule, ion or peptide binding sites. CanBind represents a complementary approach to existing methods, as it directly uses structural information in the context of large-scale cancer resequencing data, and is a step toward providing mechanistic interpretations of the effects of mutations. One important aspect of this approach is that it can highlight genes that may be infrequently mutated overall, but for which mutations preferentially occur in binding sites.