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Cancer-specific High-throughput Annotation of Somatic Mutations CHASM/SNV-Box

A software toolkit to prioritize SNVs based on their predicted contribution to tumorigenesis. CHASM includes a database of pre-computed predictive features called SNVBox that facilitates rapid feature retrieval and classification of very large SNV datasets. Furthermore, the features in SNVBox can be generally used to aid in the development of new classification algorithms that predict the impact of either germline or somatic SNVs.

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CHASM/SNV-Box classification

  • Animals
    • Homo sapiens

CHASM/SNV-Box specifications

Software type:
Restrictions to use:
Programming languages:
C++, Python
Computer skills:
Command line interface
Operating system:
Database management system:

CHASM/SNV-Box distribution


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CHASM/SNV-Box support


  • Rachel Karchin <>


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Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, USA

Link to literature

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