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- person_outline Adam Godzik
- person_outline Thomas Hrabe
Publications for Cancer3D
Mapping genetic variations to three dimensional protein structures to enhance variant interpretation: a proposed framework
[…] genetic variations and protein structure are not always easy to find. A few computational tools have begun to emerge (cBioPortal , COSMIC-3D , CRAVAT , Jalview , MuPIT , MutDB , STRUM , Cancer3D ) that enable users to take individual genetic variations, or a list of them, and visualize these in the context of protein structures. For example, CRAVAT  allows a user to upload a vari […]
Spatial distribution of disease associated variants in three dimensional structures of protein complexes
[…] such loci contain at least one nsSNV with a high predicted functional impact. Meta-methods and databases that combine several prediction tools using statistical learning have also been developed., , Cancer3D maps nsSNVs from The Cancer Genome Atlas (TCGA) and the Cancer Cell Line Encyclopedia (CCLE) onto 3D structures of the corresponding proteins and annotates them with respect to predicted canc […]
Analysis of Individual Protein Regions Provides Novel Insights on Cancer Pharmacogenomics
[…] d within) a Pfam domain. Note also that these numbers refer to PFRs in all known protein isoforms according to ENSEMBL v72. While the results for all these PFR-Drug pairs can be browsed at http://www.cancer3d.org , in this manuscript we only discuss results obtained for the largest isoform of each protein (). A similar protocol to assign protein functional regions was used in our previous publicat […]
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