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Publication for Cancer Drug Resistance database
KRDS: a web server for evaluating drug resistance mutations in kinases by molecular docking
[…] ase sequences underlying HIV drug resistance . Sibley and Ringwald  outlined how to construct a publicly accessible database containing information related to antimalarial drug resistance. In the Cancer Drug Resistance Database (CancerDR), the pharmacological profiles of 148 anticancer drugs against around 1000 cancer cell lines were deposited with 116 drug-target relations . The association […]
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts
[…] GEnomics-driven Therapy (TARGET, version 3, assessed on 6/15/2015), Personalized Cancer Therapy (PCT, assessed on 3/15/2015), GDKD (Gene-Drug Knowledge Database, version 11.0, assessed on 4/10/2015), CancerDR (assessed on 2/6/2015), My Cancer Genome (assessed on 9/11/2014), and DrugBank (assessed on 9/21/2015). We curated the list based on evidence level and literature, as well as IC50 data when a […]
Ranking novel cancer driving synthetic lethal gene pairs using TCGA data
[…] Regarding the mutation information in the CancerDR database , three cancer cell lines were selected (Table ). MCF-7 is a breast cancer cell line, carrying wild type TP53 and PRKCA. FaDu is a human epithelial cell line with mutant TP53 and S […]
Human cancer databases (Review)
[…] bstacle in cancer therapies is the development of drug resistance based on mutations in drug targets. Therefore, it is important to identify mutations in drug targets responsible for drug resistance. CancerDR () provides information of 148 anticancer drugs and their pharmacological profiling across ~1,000 cancer cell lines. Pharmacological profiling information of these anticancer drugs was collec […]
A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high throughput screening
[…] dditional file A), while there is no overlap between the predictions of the two approaches. Also, we compiled a list of known drug targets (116 targets) of very well-studied anti-cancer drugs using a cancer drug resistance database (CancerDR) . Our predictions overlap significantly with these known anti-cancer drug targets (P-value = 8.29 × 10-54; Additional file B). About 60% of known anti-canc […]
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