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CancerDR specifications

Information


Unique identifier OMICS_03987
Name CancerDR
Alternative name Cancer Drug Resistance database
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


Publication for Cancer Drug Resistance database

CancerDR citations

 (5)
library_books

KRDS: a web server for evaluating drug resistance mutations in kinases by molecular docking

2018
J Cheminform
PMCID: 5891443
PMID: 29633047
DOI: 10.1186/s13321-018-0274-y

[…] ase sequences underlying HIV drug resistance []. Sibley and Ringwald [] outlined how to construct a publicly accessible database containing information related to antimalarial drug resistance. In the Cancer Drug Resistance Database (CancerDR), the pharmacological profiles of 148 anticancer drugs against around 1000 cancer cell lines were deposited with 116 drug-target relations []. The association […]

library_books

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

2017
Nat Commun
PMCID: 5379071
PMID: 28348404
DOI: 10.1038/ncomms14864

[…] GEnomics-driven Therapy (TARGET, version 3, assessed on 6/15/2015), Personalized Cancer Therapy (PCT, assessed on 3/15/2015), GDKD (Gene-Drug Knowledge Database, version 11.0, assessed on 4/10/2015), CancerDR (assessed on 2/6/2015), My Cancer Genome (assessed on 9/11/2014), and DrugBank (assessed on 9/21/2015). We curated the list based on evidence level and literature, as well as IC50 data when a […]

library_books

Ranking novel cancer driving synthetic lethal gene pairs using TCGA data

2016
Oncotarget
PMCID: 5342422
PMID: 27438146
DOI: 10.18632/oncotarget.10536

[…] Regarding the mutation information in the CancerDR database [], three cancer cell lines were selected (Table ). MCF-7 is a breast cancer cell line, carrying wild type TP53 and PRKCA. FaDu is a human epithelial cell line with mutant TP53 and S […]

library_books

Human cancer databases (Review)

2014
PMCID: 4254674
PMID: 25369839
DOI: 10.3892/or.2014.3579

[…] bstacle in cancer therapies is the development of drug resistance based on mutations in drug targets. Therefore, it is important to identify mutations in drug targets responsible for drug resistance. CancerDR () provides information of 148 anticancer drugs and their pharmacological profiling across ~1,000 cancer cell lines. Pharmacological profiling information of these anticancer drugs was collec […]

library_books

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high throughput screening

2014
Genome Med
PMCID: 4143549
PMID: 25165489
DOI: 10.1186/s13073-014-0057-7

[…] dditional file A), while there is no overlap between the predictions of the two approaches. Also, we compiled a list of known drug targets (116 targets) of very well-studied anti-cancer drugs using a cancer drug resistance database (CancerDR) []. Our predictions overlap significantly with these known anti-cancer drug targets (P-value = 8.29 × 10-54; Additional file B). About 60% of known anti-canc […]

Citations

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CancerDR institution(s)
Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh, India

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