CANGS statistics

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Citations per year

Number of citations per year for the bioinformatics software tool CANGS

Tool usage distribution map

This map represents all the scientific publications referring to CANGS per scientific context
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Associated diseases

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CANGS specifications


Unique identifier OMICS_01084
Alternative name Cleaning and Analyzing Next Generation Sequences
Software type Package/Module
Interface Command line interface
Restrictions to use None
Biological technology Roche
Operating system Unix/Linux, Mac OS
Programming languages Perl
License GNU General Public License version 3.0
Computer skills Advanced
Version 1.1
Stability Stable
BioPerl, BLAST, MAFFT, MOTHUR, Analytic Rarefaction
Maintained Yes


No version available



  • person_outline Christian Schlotterer

Publication for Cleaning and Analyzing Next Generation Sequences

CANGS citations


Protistan community analysis: key findings of a large scale molecular sampling

PMCID: 4989302
PMID: 26859769
DOI: 10.1038/ismej.2016.10
call_split See protocol

[…] my Database (; RefSeq Release 57 (14 January 2013)) to annotate the OTUs with taxonomic information. For reasons of comparison, we also processed our data with the CANGS pipeline () and received similar results. […]


Forest Age and Plant Species Composition Determine the Soil Fungal Community Composition in a Chinese Subtropical Forest

PLoS One
PMCID: 3694989
PMID: 23826151
DOI: 10.1371/journal.pone.0066829

[…] The searches were based on blastn against the NCBI nucleotide database for fungi excluding uncultured and environmental sequences using the blast based taxonomic assignment script of the software for Cleaning and Analyzing Next Generation Sequences - CANGS .Representative sequences of OTUs of the fungal ITS pyrotags assigned under the fungal kingdom were checked for chimeras using the chimera uchi […]


Differences in Soil Fungal Communities between European Beech (Fagus sylvatica L.) Dominated Forests Are Related to Soil and Understory Vegetation

PLoS One
PMCID: 3475711
PMID: 23094057
DOI: 10.1371/journal.pone.0047500

[…] ccording to the NCBI taxonomy based on a blast search against the NCBI nucleotide database excluding uncultured sequences and environmental samples followed by a 66% consensus level as implemented in CANGS . A total of 1744 reads, which were not assigned to the fungal kingdom were cleared from the sequence dataset.To facilitate screening of potentially chimeric sequences, we established a referenc […]


CANGS DB: a stand alone web based database tool for processing, managing and analyzing 454 data in biodiversity studies

BMC Res Notes
PMCID: 3146855
PMID: 21718534
DOI: 10.1186/1756-0500-4-227

[…] CANGS DB uses the CANGS [] taxonomy analysis pipeline to assign a taxonomic path to the newly sequenced 454 reads. CANGS taxonomy analysis pipeline does not rely on a pre-curated database for either 1 […]


CLOTU: An online pipeline for processing and clustering of 454 amplicon reads into OTUs followed by taxonomic annotation

BMC Bioinformatics
PMCID: 3120705
PMID: 21599929
DOI: 10.1186/1471-2105-12-182

[…] g. We would argue that such a procedure, relying on e.g. GenBank matches, is problematic and may influence the clustering. It seems a better option to cluster sequences prior to taxonomic annotation. CANGS and SEQTRIM do not provide clustering options. In the RDP pipeline, alignment is required before clustering, something that is highly problematic when working with more variable sequences than 1 […]


Contrasting seasonal niche separation between rare and abundant taxa conceals the extent of protist diversity

Mol Ecol
PMCID: 2916215
PMID: 20609083
DOI: 10.1111/j.1365-294X.2010.04669.x

[…] sequences of each of the other samples and used a BLAST similarity cutoff of 100% to identify non-redundant sequences of a given month in each of the other months. The procedure is implemented in the CANGS software package described in . For each monthwise sample we determined the number of distinct OTUs (i), the frequency of each of these OTUs in other samples (N) and the number of reads for this […]

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CANGS institution(s)
Institut für Populationsgenetik, Veterinärmedizinische Universität Wien, Vienna, Austria

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