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Capillary electrophoresis (CE) is one of the most powerful and widely used nucleic acid separation techniques available (Weinberger, 2000). Its conventional application areas include genomic mapping, forensic identification and genome sequencing Luckey et al., 1990; Woolley et al., 1995). Recently combined with chemical probing methodologies, CE further provides a powerful and rapid means to map complex DNA and RNA structures at single-nucleotide resolution (Weeks et al., 2010).
(Weinberger, 2000) Practical Capillary Electrophoresis. 2nd Edition. Academic Press.
(Luckey et al., 1990) High speed DNA sequencing by capillary electrophoresis. Nucleic Acids Research.
(Woolley et al., 1995) Ultra-high-speed DNA sequencing using capillary electrophoresis chips. Anal. Chem.
(Weeks et al., 2010) Advances in RNA structure analysis by chemical probing. Curr. Opin. Struct. Biol.
(Kim et al., 2013) HiTRACE-Web: an online tool for robust analysis of high-throughput capillary electrophoresis. Nucleic Acids Research.