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Protocols

CAPITO specifications

Information


Unique identifier OMICS_12750
Name CAPITO
Alternative name CD Anaylsis and Plotting Tool
Interface Web user interface
Restrictions to use None
Input data Spectral data in millidegrees or mean residue CD extinction coefficient or mean residue ellipticity, respectively, can be submitted in different data formats as text (txt) file: AVIV 60DS, Aviv, Aviv CDS, BP and Jasco.
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Christoph Wiedemann

Publication for CD Anaylsis and Plotting Tool

CAPITO citations

 (7)
call_split

Prime boost vaccination with recombinant protein and adenovirus vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge

2018
Sci Rep
PMCID: 5773670
PMID: 29348479
DOI: 10.1038/s41598-017-19063-6
call_split See protocol

[…] s subtracted from each protein spectrum. The data were smoothed with a Savitzky-Golay filter, and the percentages of secondary structure were predicted using the CD Analysis and Plotting Tool (http://capito.nmr.leibniz-fli.de/index.php). […]

library_books

Small amphipathic peptides are responsible for the assembly of cruciferin nanoparticles

2017
Sci Rep
PMCID: 5552735
PMID: 28798358
DOI: 10.1038/s41598-017-07908-z

[…] ed an average of five scans that were collected in 1 nm step at a rate of 20 nm/min over the wavelength range of 190–250 nm. The raw data were corrected by conversion to mean residue ellipticity. The CAPITO method was used to perform the CD curve fitting and quantify the secondary structure. […]

library_books

The N Terminal Region of the Ryanodine Receptor Affects Channel Activation

2017
Front Physiol
PMCID: 5492033
PMID: 28713282
DOI: 10.3389/fphys.2017.00443

[…] nformation. In ethanol (Figure ), the ellipticity was an order of magnitude higher, without a substantial change in the shape of the spectra. The content of α-helix was estimated using the web server CAPITO (http://capito.nmr.leibniz-fli.de/index.php) to be 99%. The high content of α-helix estimated from CD spectra shows that the structure of DPcpvtN2 in solution is comparable to the structure of […]

library_books

DNA‐induced unfolding of the thyroid hormone receptor α A/B domain through allostery

2017
FEBS Open Bio
PMCID: 5458466
PMID: 28593140
DOI: 10.1002/2211-5463.12229

[…] spectra accumulations, averaged and smoothed. All the spectra were corrected for the contributions of the buffer and TRE DR4 . Mean residue ellipticity ([θ], (deg cm2 dmol−1) was calculated using the capito software . […]

library_books

Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4

2015
Int J Mol Sci
PMCID: 4490436
PMID: 26030674
DOI: 10.3390/ijms160612159

[…] The secondary structure of PepE and PepK in PBS was studied by circular dichroism (CD) spectroscopy and analyzed by the CAPITO web server (http://capito.nmr.fli-leibniz.de). As expected for very short peptide sequences, both peptides did not show any tendency to fold under this experimental condition []. CD spectra () […]

library_books

Features of Two New Proteins with OmpA Like Domains Identified in the Genome Sequences of Leptospira interrogans

2015
PLoS One
PMCID: 4388678
PMID: 25849456
DOI: 10.1371/journal.pone.0122762

[…] ane 1). Structural integrity of the purified proteins was assessed by circular dichroism (CD) spectroscopy, depicted in for Lsa46 and for Lsa77, and the spectral data per wavelength analyzed by the CAPITO software []. The results show 10, 36 and 51% of alpha helix, beta-strands and random for Lsa46, and 21, 0.1 and 70% of alpha helix, beta-strands and random secondary structures in the case of L […]

Citations

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CAPITO institution(s)
Biomolecular NMR Spectroscopy, Leibniz Institute for Age Research—Fritz Lipmann Institute, Jena, Germany

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