Carbonylation site databases | Post-translational modification data analysis
Protein carbonylations are widely recognized as the biomarkers for oxidative stress, protein damage, aging/senescence, age-related diseases, and numerous degenerative/other diseases including cancer. While all bio-molecules are prone to oxidative damage, proteins are particularly vulnerable and critical targets because most of the cellular functional-biomass is proteins. A database that provides easy access to information on experimentally-confirmed carbonylated proteins/sites would therefore be a very valuable resource.
Provides experimentally-confirmed carbonylated proteins/sites. CarbonylDB is a manually-curated resource that provides a user-friendly web-interface for searching, browsing, and downloading data. This resource contains more than 1450 carbonylated proteins and more than 3700 sites from 21 species. It permits to assist comparative analyses and hypothesis generation, to select prospective candidates as in vitro models, and to develop potential in vivo biomarkers for oxidative protein damage.
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