Carboxylation site detection software tools | Post-translational modification data analysis
In proteins, glutamate (Glu) residues are transformed into carboxyglutamate (Gla) residues in a process called carboxylation to aid in various cellular mechanisms. Carboxylation is a post-translational modification (PTM) of Glu residues in proteins wherein a carboxylic acid group is added into a substrate protein. The process of Carboxylation plays a significant role in a wide array of biological processes. It is primarily involved in the blood clotting cascade.
Identifies carboxylated proteins with modification sites in order to investigate the biological functions of carboxylated proteins. Users can submit their uncharacterized protein sequences, then, Carboxylator, returns the predictions, including the carboxylated position, flanking amino acids, and the probability of carboxylation. With regard to the functional analysis of carboxylated proteins, the implementation of the proposed prediction scheme effectively helps users to elucidate the biological function of an uncharacterized protein.