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Cascade | A R package to study, predict and simulate the diffusion of a signal through a temporal gene network


Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network.

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Cascade classification

Cascade specifications

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Cascade distribution


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Cascade support


  • Myriam Maumy-Bertrand <>


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INSERM UMR S_1109, Labex Transplantex, FMTS, Hôpitaux and Faculté de Médecine, Université de Strasbourg, Strasbourg, France; IRMA, Labex IRMIA, Université de Strasbourg, Strasbourg, France

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