tutorial arrow
Create your own tool library
Bookmark tools and put favorites into folders to find them easily.

CASE-BBB prediction


Predicts Blood-Brain-Barrier (BBB) permeability from drug clinical phenotypes (drug side effects and drug indications). CASE-BBB prediction can apply to both small compounds and macro-molecules penetrating BBB through various mechanisms besides passive diffusion. It accounts for passive diffusion as well as a putative contribution by active transport and other complex mechanisms. This method not only applies to the Food and Drug Administration (FDA) approved drugs but also applies to the tested/testing drugs, the failed drugs due to lack of expected efficiency, and the withdrawn drugs due to toxic or others reasons, as long as clinical phenotype data of these drugs are available.

User report

tutorial arrow
Vote up tools and offer feedback
Give value to tools and make your expertise visible

0 user reviews

0 user reviews

No review has been posted.

CASE-BBB prediction forum

tutorial arrow
Communicate with other users
Participate in the forum to get support for using tools. Ask questions about technical specifications.

No open topic.

CASE-BBB prediction versioning

tutorial arrow
Upload and version your source code
Get a DOI for each update to improve tool traceability. Archive your releases so the community can easily visualize progress on your work.

No versioning.

CASE-BBB prediction classification

CASE-BBB prediction specifications

Software type:
Restrictions to use:
Computer skills:
Command line interface
Operating system:

CASE-BBB prediction support



  • Rong Xu <>


tutorial arrow
Promote your skills
Define all the tasks you managed and assign your profile the appropriate badges. Become an active member.



Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA; Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, USA

Funding source(s)

This project is funded by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under the NIH Directors New Innovator Award number DP2HD084068.

By using OMICtools you acknowledge that you have read and accepted the terms of the end user license agreement.