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CASINO specifications


Unique identifier OMICS_27701
Alternative name Community And Systems-level INteractive Optimization


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Publication for Community And Systems-level INteractive Optimization

CASINO citations


Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells

Front Mol Biosci
PMCID: 5767226
PMID: 29376056
DOI: 10.3389/fmolb.2017.00096

[…] al., ). Furthermore, GEMs derived from human gut microbiome were used to decipher microbe-microbe, diet-microbe and microbe-host interactions. Another GEM based comprehensive computational platform, CASINO (Community And Systems-level INteractive Optimization) was designed to study the effect of diet on microbial communities (Shoaie et al., ). […]


The Human Mucosal Mycobiome and Fungal Community Interactions

PMCID: 5753158
PMID: 29371572
DOI: 10.3390/jof3040056

[…] between them to the overall simplified community metabolism and elucidate the interactions between the bacteria [,]. Through the generation of comprehensive toolboxes for community modeling, such as CASINO (Community And Systems-level INteractive Optimization), and the use of GEMs for predominant bacteria in human gut, the alteration in the amino acid profile of both feces and serum in response t […]


Elucidation of complexity and prediction of interactions in microbial communities

PMCID: 5658597
PMID: 28925555
DOI: 10.1111/1751-7915.12855

[…] nities to predict time‐varying interactions between species and their effects on microbial composition. This approach is referred to as dynamic multispecies metabolic modelling (Zhuang et al., ). The CASINO toolbox (Community And Systems‐level INteractive Optimization) was created as a comprehensive platform to analyse gut microbial communities (Shoaie et al., ). The authors used experimental data […]


More than just a gut feeling: constraint based genome scale metabolic models for predicting functions of human intestinal microbes

PMCID: 5512848
PMID: 28705224
DOI: 10.1186/s40168-017-0299-x

[…] esses. By combining previous approaches of modeling interspecies interactions and considering the whole microbiota as one entity, a predictive tool for dietary interventions was created []. The tool, CASINO—Community And Systems-level Interactive and Optimization—predicts dietary interventions based on interactions between the host, the microbiota, and the applied diet. CASINO was used to model th […]


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CASINO institution(s)
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Institut National de la Recherche Agronomique (INRA), Nutrition Humaine, Plateforme Exploration du Metabolisme, Clermont-Ferrand, France; Institut National de la Recherche Agronomique (INRA), UMR1319 Micalis and USR1367 MetaGenoPolis, Jouy-en-Josas, France; Institute of Cardiometabolism and Nutrition (ICAN), Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM), U1166, NutriOmics Team 6, Paris, France; Section of Biomolecular Medicine, Department of Surgery and Cancer, Division of Computational and Systems Medicine, Faculty of Medicine, Imperial College London, London, UK; Sorbonne Universites, UPMC University Paris 06, UMR S-1166, Paris, France; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
CASINO funding source(s)
Supported by the Knut and Alice Wallenberg Foundation, the Bill & Melinda Gates Foundation, Torsten Soderbergs Stiftelse, European Commission FP7 project METACARDIS with the grant agreement HEALTH-F4-2012-305312, Fondation Cœur et Arteres, and the French National Agency of Research (ANR MicroObes and ‘‘Investissements d’avenir’’ ANR-10-IAHU-05).

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