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Cascleave | An approach for predicting caspase and granzyme cleavage targets


Allows high-throughput in silico identification of substrate cleavage sites for various caspases from the amino acid sequences of the substrates. Cascleave aims to identify novel substrates and cleavage sites of caspases and granzyme B (GrB). It assists users to understand the functional roles of these important proteases in human proteolytic cascades. This tool employs a two-step integrative framework to characterize protein sequence.

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Cascleave classification

Cascleave specifications

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Caspase substrate cleavage site prediction
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Cascleave distribution


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National Engineering Laboratory for Industrial Enzymes and Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin308, Department of Computer Science, School of Electronics and Information Engineering, Tongji University, Shanghai, China; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia; Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan; ARC Centre of Excellence for Structural and Functional Microbial Genomics, Monash University, Melbourne, Victoria, Australia

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