CATHEDRAL statistics

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Citations per year

Number of citations per year for the bioinformatics software tool CATHEDRAL

Tool usage distribution map

This map represents all the scientific publications referring to CATHEDRAL per scientific context
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CATHEDRAL specifications


Unique identifier OMICS_13712
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Oliver Redfern

Publication for CATHEDRAL

CATHEDRAL citations


The history of the CATH structural classification of protein domains

PMCID: 4678953
PMID: 26253692
DOI: 10.1016/j.biochi.2015.08.004

[…] more recent STRUCTAL , and FATCAT algorithms, this was not problematic in the mid 80s when there were fewer than 2000 protein structures in the PDB (a faster version of the method is now available: CATHEDRAL ).Around this time, Janet Thornton, an expert in detailed studies of protein structure who had characterized various structural motifs like the alpha–beta-motifs , beta-turns , , recognised […]


Exposure to cold weather during a mass gathering in the Philippines

Bull World Health Organ
PMCID: 4622163
PMID: 26549910
DOI: 10.2471/BLT.15.158089

[…] f Palo and Tacloban, which coincided with the landfall of tropical storm Mekkhala. During his visit in Palo and Tacloban, he conducted an open-air service, visited the archbishop’s residence and Palo Cathedral. The visit attracted large crowds and specific planning was done ahead of time. The pre-event planning focused on hyperthermia, crowd safety and control, but had not considered the risk pose […]


Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains

Nucleic Acids Res
PMCID: 3531217
PMID: 23203986
DOI: 10.1093/nar/gks1266

[…] s with manual curation to detect homologous domains, SCOP relies more heavily on manual curation. For CATH, homologs are automatically recognized using in-house structure comparison methods [SSAP (), CATHEDRAL () and Hidden Markov Model (HMM)-based strategies ()]. In addition to differences in protocols for structure classification, SCOP and CATH use somewhat different criteria for recognizing dom […]


1,000 structures and more from the MCSG

BMC Struct Biol
PMCID: 3024214
PMID: 21219649
DOI: 10.1186/1472-6807-11-2

[…] ally novel and belongs to a new structural sub-group (SSG). Both MCSG domains assigned to CATH and unassigned MCSG PDB chains are compared to a representative library of CATH domains (S35 reps) using CATHEDRAL [] as a fast filter for significant structural similarity. The best matches by CATHEDRAL are then structurally aligned and superposed using the more computationally expensive and accurate me […]


Accurate Protein Structure Annotation through Competitive Diffusion of Enzymatic Functions over a Network of Local Evolutionary Similarities

PLoS One
PMCID: 3001439
PMID: 21179190
DOI: 10.1371/journal.pone.0014286

[…] usion soar, but this is expected from the extremely low confidence of the predictions past that point (the z-score is below −0.05). Since FLORA was itself superior to other template methods, such as CATHEDRAL and Reverse Templates , these results suggest that ETA network diffusion also outperforms these approaches. […]


Extending CATH: increasing coverage of the protein structure universe and linking structure with function

Nucleic Acids Res
PMCID: 3013636
PMID: 21097779
DOI: 10.1093/nar/gkq1001

[…] cludes the development of a single web-based portal through which users can access the data provided by both CATH and Gene3D. All the usability of the original site is being maintained, including the CATHEDRAL () and SSAP (,) web servers for structural comparison. Users are able to browse though the hierarchy in the same manner as previous incarnations of the website.The CATH superfamily pages, ho […]

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CATHEDRAL institution(s)
Department of Biochemistry and Molecular Biology, University College London, London, UK; Department of Mathematical Sciences and Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK
CATHEDRAL funding source(s)
This work was partly funded by an Engineering and Physical Sciences Research Council (EPSRC) studentship, a Biotechnology and Biological Sciences Research Council (BBSRC) studentship and the Medical Research Council.


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