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CBTOPE specifications


Unique identifier OMICS_06714
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for CBTOPE

CBTOPE citations


Virulence factors of Moraxella catarrhalis outer membrane vesicles are major targets for cross reactive antibodies and have adapted during evolution

PMCID: 5862889
PMID: 29563531
DOI: 10.1038/s41598-018-23029-7

[…] families in the studied genomes were taken from orthomcl results., sequences of immunoreactive proteins were searched for potential epitopes using 15 predictive approaches: aap, bcpred, bepipred, cbtope, cobepro, fbcpred, igpred, svmtrip, as well as bcepred based on seven amino acid physico-chemical scales, hydrophilicity, flexibility, accessibility, turns, antigenic propensity, exposed […]


Fundamentals and Methods for T and B Cell Epitope Prediction

PMCID: 5763123
PMID: 29445754
DOI: 10.1155/2017/2680160

[…] [] ()., as remarked before, methods for conformational b-cell epitope prediction generally require the 3d-structure of the antigen. exceptionally, however, ansari and raghava [] developed a method (cbtope) for the identification of conformational b-cell epitope from the primary sequence of the antigen. cbtope is based on svm and trained on physicochemical and sequence-derived features […]


Staged heterogeneity learning to identify conformational B cell epitopes from antigen sequences

PMCID: 5374683
PMID: 28361709
DOI: 10.1186/s12864-017-3493-0

[…] a data set with computationally defined epitopes. this proposed sequence-based method achieved outstanding performance - about twice that of existing methods, including the sequence-based predictor cbtope and three other structure-based predictors., the proposed method uses only antigen sequence information, and thus has much broader applications., b-cell immunity provides a natural barrier […]


Enhancing the Biological Relevance of Machine Learning Classifiers for Reverse Vaccinology

PMCID: 5343848
PMID: 28157153
DOI: 10.3390/ijms18020312

[…] could be due to the difficulty in predicting conformational epitopes from amino acid sequences [], it is estimated that 90% of b-cell epitope binding is conformational []. to model this information cbtope [] (a conformational b-cell epitope predictor) was included in this study, however annotation features derived from cbtope were not present in the top ten annotation features used […]


An Introduction to B Cell Epitope Mapping and In Silico Epitope Prediction

PMCID: 5227168
PMID: 28127568
DOI: 10.1155/2016/6760830

[…] at 0.81 and 0.85 for the fragment-based prediction and 0.57 and 0.6 for full antigen. best outperforms several modern sequence-based b-cell epitope predictors including abcpred, bcpred, cobepro, and cbtope []., svmtrip employs support vector machine to combine the tripeptide similarity and propensity scores to predict linear epitopes. svmtrip achieves a sensitivity of 80.1% and a precision […]


A Platform for Designing Genome Based Personalized Immunotherapy or Vaccine against Cancer

PMCID: 5104390
PMID: 27832200
DOI: 10.1371/journal.pone.0166372

[…] for predicting hla class ii binders. this software allows prediction of promiscuous hla class ii binders that can bind to a large number of alleles., there are numerous methods such as bcepred [], cbtope [], lbtope [], discotope [], cobepro [] available for predicting b-cell epitopes. we employed a standalone version of lbtope software for the prediction of linear b-cell epitopes. in order […]

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CBTOPE institution(s)
Bioinformatics Center, Institute of Microbial Technology, Chandigarh, India

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