CCAST specifications


Unique identifier OMICS_30028
Alternative name Clustering, Classification and Sorting Tree
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


  • person_outline Sylvia Plevritis

Publication for Clustering, Classification and Sorting Tree

CCAST citation


DRUG NEM: Optimizing drug combinations using single cell perturbation response to account for intratumoral heterogeneity

Proc Natl Acad Sci U S A
PMCID: 5939057
PMID: 29654148
DOI: 10.1073/pnas.1711365115

[…] N1 and UPN7, respectively.To account for intratumor heterogeneity, we initiated DRUG-NEM with a minimum of five subpopulations based on exploratory clustering with SPADE () (Fig. S5) and then applied CCAST to identify and match seven cell subpopulations across the three inhibitors and basal (pretreatment) conditions for each patient sample (). The CCAST-derived decision trees that define the subpo […]

CCAST institution(s)
Department of Radiology, Center for Cancer Systems Biology, Stanford University, Stanford, CA, USA
CCAST funding source(s)
Supported by NCI U54 CA149145 grant and the Gary M. Glazer Gift Fund.

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