Tackles the problem for a defined but large class of protein structure, the alpha-helical coiled coils. CCBuilder generates coiled-coil backbones, builds side chains onto these frameworks and provides a range of metrics to measure the quality of the models. Its straightforward graphical user interface (GUI) provides broad functionality that allows users to build and assess models, in which helix geometry, coiled-coil architecture and topology and protein sequence can be varied rapidly.
School of Chemistry, University of Bristol, Cantock’s Close, Bristol, UK; School of Biochemistry, University of Bristol, Medical Sciences Building, University Walk, Bristol, UK; BrisSynBio, University of Bristol, Life Sciences Building, Bristol, UK
CCBuilder funding source(s)
Supported by grants from the European Research Council (340764) and BBSRC/ERASynBio (BB/M005615/1).