Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 12
Access: Public
Diseases: Fanconi Syndrome
Genes: TOX, TOX2, TOX3
Taxon: Homo sapiens, Rattus norvegicus
Dataset link Expression data in HK-2 cells following exposure to CdCl

Experimental Protocol


Gene expression changes in HK-2 cells were measured following exposure to 9 different compounds over a range of doses and time-points with the aim of finding biological signatures of toxicity. Clustering of the resulting gene expression data revealed 3 groups of nephrotoxic compounds (Tox 1, Tox 2 and Tox 3), each exhibiting their own distinct effect on HK-2 cells. This study measures gene expression changes following exposure to CdCl or control over 12 hrs or 48 hrs. Three biological replicates per compound/time-point.

Repositories


GEO

GSE27094

BioProject

PRJNA141949

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