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Citations per year

Number of citations per year for the bioinformatics software tool CCLab
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This map represents all the scientific publications referring to CCLab per scientific context
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CCLab specifications

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Unique identifier OMICS_04996
Name CCLab
Alternative name Combinatorial Chemistry Laboratory
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability No
Maintained No

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Publication for Combinatorial Chemistry Laboratory

CCLab citations

 (5)
library_books

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene Expression Based Retrospective Study

2016
PLoS Med
PMCID: 5154505
PMID: 27959923
DOI: 10.1371/journal.pmed.1002194

[…] sing the methods described above.All analyses were conducted using R version 3.3 [] or Stata SE version 14.1 (StataCorp). The complete dataset used for all analyses is available at https://github.com/cclab-brca. […]

library_books

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

2016
Nat Commun
PMCID: 4866047
PMID: 27161491
DOI: 10.1038/ncomms11479

[…] , and may be downloaded on request and authorization by the METABRIC Data Access Committee. Somatic mutation calls and ASCAT segment files for 2,433 primary tumours are available at http://github.com/cclab-brca, which also hosts the code used to perform key analyses and produce the figures. A matrix of coding mutations is provided as . Clinical data (tumour morphology, ER and HER2 status, patient […]

library_books

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

2016
PMCID: 4724696
PMID: 26904403
DOI: 10.1016/j.apsb.2015.11.002

[…] ree characteristic structural features: a critical zinc-binding region, a hydrophobic region referred as CAP, and a linker between these two regions.In our previous work we designed a software called CCLab (Combinatorial Chemistry Laboratory) and applied it for the identification of new chemical scaffolds of HDAC inhibitors. Based on the screening results, the scaffold of tetrahydroisoquinoline () […]

library_books

Astronomical algorithms for automated analysis of tissue protein expression in breast cancer

2013
Br J Cancer
PMCID: 3593538
PMID: 23329232
DOI: 10.1038/bjc.2012.558

[…] the east of England with breast cancer. We included 2258 breast tumours and have made digital images for all three markers and reported algorithms freely accessible at: https://www.cri.cam.ac.uk/data/cclab/; username: cclabpub; password: uwzuhq8n. […]

library_books

Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin Bound Unnatural Amino Acids and Virtual D3 Catalog Construction

2008
PMCID: 2651687
PMID: 19105725
DOI: 10.1021/cc800184v

[…] resulting virtual D3 catalog, further demonstrating the potential of Distributed Drug Discovery. Accordingly, we modified our published synthesis of 1() and incorporated the rehearsal into a student combinatorial chemistry laboratory that transformed 1 to the acylated derivatives 5 (Scheme ). This generic structure 5 would then become the basis of our first virtual D3 catalog.The time ranges show […]


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CCLab institution(s)
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; National Drug Screening Center, Shanghai, China
CCLab funding source(s)
Supported by the State Key Laboratory of Drug Research, National Science & Technology Major Project ‘‘Key New Drug Creation and Manufacturing Program’’ of China (Grant No. 2009ZX09501-010), Program of Excellent Young Scientist of Chinese Academy of Sciences (Grant No. KSCX2-EW-Q-3-01) and the National Natural Science Foundation of China (Grant 81072580 and 81102306).

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