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CCP-EM specifications


Unique identifier OMICS_26613
Alternative name Computational Project for Electron cryo-Microscopy
Software type Application/Script
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS
Computer skills Advanced
Stability Beta
Maintained Yes


No version available


  • person_outline CCP-EM Team

Publications for Computational Project for Electron cryo-Microscopy

CCP-EM citations


Cryo EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

PMCID: 5962338
PMID: 29726815
DOI: 10.7554/eLife.35946.020
call_split See protocol

[…] nduced motion and performs experimental dose-weighting) did not improve the quality of the density. Local resolution was calculated with RELION.Model building and refinement was carried out using the CCP-EM software suite (). The activated A2AR and mini-GS coordinates were taken as starting models (PDB code 5g53) together with the βγ coordinated from the β2AR complex structure (). Jelly-body refin […]


Automating tasks in protein structure determination with the clipper python module

PMCID: 5734304
PMID: 28901669
DOI: 10.1002/pro.3299

[…] nough for representing textual data, and both have libraries available for reading and writing results from major scripting languages. As real‐world examples, both the Protein Data Bank in Europe and CCP‐EM represent their structural data objects in JSON internally, while the choice within CCP4i2 and clipper_tools has been XML.As an example of a structured‐data report in XML:


Introducing the Proceedings of the CCP EM Spring Symposium

Acta Crystallogr D Struct Biol
PMCID: 5458487
PMID: 28580907
DOI: 10.1107/S2059798317008002

[…] This special issue is the inaugural edition of Proceedings of the CCP-EM Spring Symposium. The symposium is an annual conference which aims to review and highlight state-of-the-art developments in macromolecular cryo-electron microscopy in an accessible and convivia […]


Electron Bio Imaging Centre (eBIC): the UK national research facility for biological electron microscopy

Acta Crystallogr D Struct Biol
PMCID: 5458490
PMID: 28580910
DOI: 10.1107/S2059798317007756

[…] l power (CPU and GPU) tightly coupled to the high-speed file system, so that a significant amount of data analysis can be supported. Work is under way with the data-analysis group at Diamond and with CCP-EM (Wood et al., 2015) to implement automated pipelines to provide real-time feedback for both single-particle and tomography applications. Underpinning this work will be the effective integration […]


High resolution cryo EM proteasome structures in drug development

Acta Crystallogr D Struct Biol
PMCID: 5458494
PMID: 28580914
DOI: 10.1107/S2059798317007021

[…] of the prototype specific Plasmodium proteasome inhibitors tested as potential antimalarials (Li, O’Donoghue et al., 2016; Li, Bogyo et al., 2016). Within the context of the proceedings of the Second CCP-EM Spring Symposium, here we review our cryo-EM analysis of ligand-bound human and P. falciparum proteasomes, focusing on a detailed description of the methods we used for structure determination, […]


Building bridges between cellular and molecular structural biology

PMCID: 5524535
PMID: 28682240
DOI: 10.7554/eLife.25835.008

[…] bed EMDB-SFF (SFF=Segmentation File Format), PDBe is developing translators to/from other commonly used formats. The code for these translators is provided as free open source and distributed via the CCP-EM SVN repository. Comments on the schema should be sent to AP. […]

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CCP-EM institution(s)
Scientific Computing Department, Science and Technology Facilities Council, Research Complex, Harwell, UK
CCP-EM funding source(s)
Supported by Medical Research Council (award Nos. MR/J000825/1, MR/N009614/1).

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