Computational protocol: Impact of childhood trauma on functionality and quality of life in HIV-infected women

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Protocol publication

[…] Data were analyzed using the Statistical Package for the Social Sciences (SPSS) for Windows, version 18.0 and Statistica, version 10. Basic statistical analyses were conducted, which included descriptive statistics. Spearman correlation coefficients were calculated for all QoL self-report measures and depression scores (CES-D) and clinical disease markers (CD4 lymphocyte count and viral load). Reliability analysis (Cronbach's alpha) was conducted on all self-report measures included in the analyses. Analysis of variance (ANOVA) was conducted to assess for group differences in demographic and clinical characteristics. Separate univariate tests of significance, namely Analysis of Covariance (ANCOVA) were computed for the Q-LES-Q and PAOFI. HIV status (HIV-positive and HIV-negative) and childhood trauma status (trauma and no trauma) were included as predictors. Covariates included: age, education, and depression scores. ANCOVA was used to assess both the individual effects and interactional effects of HIV and childhood trauma on self-perceived QoL. Fisher LSD corrections were applied. Finally, confirmatory multiple regression analysis was performed to assess the predictive power of variables of interest on QoL. […]

Pipeline specifications

Software tools SPSS, Statistica
Application Miscellaneous
Organisms Homo sapiens, Human immunodeficiency virus 2
Diseases Wounds and Injuries, HIV Infections