Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 20
Release date: Jun 10 2011
Last update date: Mar 23 2012
Access: Public
Diseases: Creutzfeldt-Jakob Syndrome, Encephalopathy, Bovine Spongiform
Dataset link Bovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis)

Experimental Protocol


Cynomolgus macaques (Macaca fasicularis) were infected intracerebrally with BSE-positive brain stem material from cattle and allowed to develop prion disease. Brain tissue from the basis pontis and vermis cerebelli of the six animals and the same regions from four healthy controls were subjected to ERV expression profiling using a retrovirus-specific microarray and quantitative real-time PCR. In a second approach, ERV-K-(HML-2) RNA and protein expression was analysed in extracts from the same cynomolgus macaques.

Repositories


GEO

GSE29818

ArrayExpress

E-GEOD-29818

BioProject

PRJNA140939

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Contact


Michelle Vincendeau