|Application:||Gene expression microarray analysis|
|Number of samples:||36|
|Release date:||Oct 30 2017|
|Last update date:||Aug 22 2018|
|Dataset link||IRF4 haploinsufficiency in a family with Whipple’s disease|
PBMCs from six IRF4-heterozygous individuals (three patients, P1-P3; and three healthy relatives, HET1-HET3) and six IRF4 WT-homozygous individuals (four healthy relatives, WT1-WT4; and two unrelated controls, C1-C2) were dispensed into a 96-well plate and were either infected in vitro with live Tw at a multiplicity of infection (MOI) of 1, with live BCG (M. bovis-BCG, Pasteur substrain) at a MOI of 20, or were left uninfected (mock). Two wells per condition were combined 24 h post-infection for total RNA isolation followed by microarray analysis.
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