Cell composition correction software tools | DNA methylation microarray data analysis
Whole blood is frequently utilized in genome-wide association studies of DNA methylation patterns in relation to environmental exposures or clinical outcomes. However, for DNA methylation assessed from whole blood, the association between DNA methylation and an exposure of interest could be confounded by cellular heterogeneity. In larger epidemiological studies, it is not feasible to isolate and profile every individual cell subset. Thus, several algorithms have been developed to measure and adjust for cellular heterogeneity in whole blood.