Cell cycle databases | Protein interaction data analysis
The process by which cells replicate and pass on their genetic information, termed the cell cycle, is fundamental to life and has been intensely studied in the biological sciences. The past decade has witnessed an explosion in data derived from cell-cycle specific and other high-throughput experiments.
A database for proteins temporally and spatially localized in distinct subcellular positions including midbody, centrosome, kinetochore, telomere and mitotic spindle during cell division/mitosis. MiCroKiTS can serve as a useful resource for further analyzing the molecular mechanisms during cell division.
Maintains a list of gene entailing in telomere maintenance (TM). TelNet provides to user information about type of TM mechanism the gene is involved. Several data are available as well as telomere specific knockdown phenotype or general cellular. It helps to work about TM networks in cancer for diagnosis, prognosis or therapy response prediction. Regarding each gene literature linking, this gene to TM features is listed. The database is curated by researchers from the consortium, as scientists studying on telomeres.
Gathers replication timing data. ReplicationDomain provides a repository that allows to investigate and make comparison between microarray data and other chromosomal properties. The database is publicly available and files can be freely downloaded as a tab-delimited text file or saved as a JPEG file. Additionally, it allows users to create their own datasets which be stored and shared according three security levels.
A database on cell cycle regulation in eukaryotes. CYCLONET contains information about cell cycle specific genes, proteins, protein complexes and their interactions, diagrams of cell cycle regulation for vertebrates, models of cell cycle and results of their analyses, microarray data, literature references and other related resources.
Gathers collated genome-wide mapping studies of confirmed and predicted replication origin sites. OriDB is an online repository that aims to simplify comparisons with a range of other chromosomal features including transcription, genomic rearrangements and fragile sites. Moreover, it allows users to access to all the datasets curated at OriDB, including those tables curated from the literature.
Allows user to submit a protein sequence to determine estimates for involvement in the cell cycle process. CellCycleDB is a resource that offers detailed analysis through homology assignment for identifying proteins functioning in the cell cycle process focusing on cell cycle control. It also provides various accuracy levels for cell cycle function assignment of all proteins among six eukaryotic proteomes.
An online resource for the kinetochore and its related proteins. KinetochoreDB provides comprehensive annotations on 1554 related protein entries in terms of their amino acid sequence, protein domain context, protein 3D structure, predicted intrinsically disordered region, protein-protein interaction, post-translational modification site, functional domain and key metabolic/signaling pathways, integrating several public databases, computational annotations and experimental results. KinetochoreDB provides interactive and customizable search and data display functions that allow users to interrogate the database in an efficient and user-friendly manner. It uses PSI-BLAST searches to retrieve the homologs of all entries and generate multiple sequence alignments that contain important evolutionary information. This knowledgebase also provides annotations of single point mutations for entries with respect to their pathogenicity, which may be useful for generation of new hypotheses on their functions, as well as follow-up studies of human diseases.